Association of Markers of Inflammation, the Kynurenine Pathway and B Vitamins with Age and Mortality, and a Signature of Inflammaging

PA Dugue; AM Hodge; A Ulvik; PM Ueland; O Midttun; S Rinaldi; RJ MacInnis; SX Li; K Meyer; AS Navionis; L Flicker; G Severi; DR English; P Vineis; GS Tell; MC Southey; RL Milne; GG Giles

Journal article

Association of Markers of Inflammation, the Kynurenine Pathway and B Vitamins with Age and Mortality, and a Signature of Inflammaging

PA Dugue, AM Hodge, A Ulvik, PM Ueland, O Midttun, S Rinaldi, RJ MacInnis, SX Li, K Meyer, AS Navionis, L Flicker, G Severi, DR English, P Vineis, GS Tell, MC Southey, RL Milne, GG Giles

Journals of Gerontology Series A Biological Sciences and Medical Sciences | OXFORD UNIV PRESS INC | Published : 2022

DOI: 10.1093/gerona/glab163

Abstract

Background: Inflammation is a key feature of aging. We aimed to (i) investigate the association of 34 blood markers potentially involved in inflammatory processes with age and mortality and (ii) develop a signature of "inflammaging."Methods: Thirty-four blood markers relating to inflammation, B vitamin status, and the kynurenine pathway were measured in 976 participants in the Melbourne Collaborative Cohort Study at baseline (median age = 59 years) and follow-up (median age = 70 years). Associations with age and mortality were assessed using linear and Cox regression, respectively. A parsimonious signature of inflammaging was developed and its association with mortality was compared with 2 m..

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University of Melbourne Researchers

Pierre-Antoine Dugue Author

Allison Hodge Author

Robert MacInnis Author

Dallas English Author

Related Projects (3)

Epidemiology of chronic disease, health interventions and DNA studies

PRECISION PUBLIC HEALTH FOR MAJOR CANCERS - NOVEL APPROACHES TO BUILDING THE GENETIC, EPIGENETIC AND LIFESTYLE KNOWLEDGE BASE FOR ASSESSING RISK AND PROGNOSIS

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THE HEALTH 2020 COHORT STUDY (HEALTH 2020)

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

The MCCS cohort recruitment was funded by VicHealth and Cancer Council Victoria. The MCCS was further augmented by Australian National Health and Medical Research Council grants 209057, 396414, 1074383, and 1106016 and by infrastructure provided by Cancer Council Victoria. Cases and their vital status were ascertained through the Victorian Cancer Registry and the Australian Institute of Health and Welfare, including the National Death Index and the Australian Cancer Database.